病理学见习课课件：Circulation+Disorders+2.ppt

Circulation Disorders Part 2 Embolism Infarction Objectives Keywords: embolism and infarction Recognize: the major morphologic changes of emboli Recognize: the subtypes of embolism and its possible effects Gross ： No.3 Anemic infarct of the spleen No.4 Hemorrhagic infarct of the lung No.13 Hemorrhagic infarct of the small intestine Slides ： No.4 Hemorrhagic infarct of the lung No.7 Tumor embolus of the lung No.16 Anemic infarct of the kidney * * Spleen, Heart, Brain, Kidney Testis/Ovary, Lung, Brain, Bowel, Liver The necrotic areas give the conical/pyramid outline on the cut surface. Gross 3 Anemic infarct of the spleen Gross 3 Anemic infarct of the spleen Note the multiple irregular necrotic areas beneath the capsule. Gross 13 Hemorrhagic infarct of small intestine No definite demarcation between the necrotic intestine and normal part (volvulus). Gross 13 Hemorrhagic infarct of small intestine The entire intestine has been necrosed because of blood vessel obstructed. Venous thrombus in the main pulmonary artery and the branch Gross 4 Hemorrhagic infarct of the lung Why lung infarcts are hemorrhagic? Gross 4 Hemorrhagic infarct of the lung Lung has a dual blood supply (bronchial artery pulmonary artery).While flow through one arterial supply is blocked, flow continues in the others through necrotic vessels. Slide 4 Hemorrhagic infarct of the lung Note the obvious hemorrhage and distinct outline under low power field. Slide 4 Hemorrhagic infarct of the lung Vague contour of alveolar septa in the hemorrhagic area, the lumens are filled with RBC. Slide 4 Hemorrhagic infarct of the lung Alveolar spaces within the infarct (right) are filled with erythrocytes and hemosiderin-laden macrophages. Slide 7 Tumor embolus of the lung Note the cell clumps in the vessels. Slide 7 Tumor embolus of the lung The tumor cell clump in a blood vessel. Slide 7 Tumor embolus of the lung Note the tumor embolus in a artery, the tumor cells resemble normal gland