病理学英文课件：repair 2013 for 8years students.ppt

* * * * * * * * * * * * * * * * Figure 3-15 Angiogenesis by mobilization of endothelial precursor cells (EPCs) from the bone marrow and from preexisting vessels (capillary growth). A, EPCs are mobilized from the bone marrow and may migrate to a site of injury or tumor growth. At these sites, EPCs differentiate and form a mature network by linking to existing vessels. B, In angiogenesis from preexisting vessels, endothelial cells from these vessels become motile and proliferate to form capillary sprouts. Regardless of the initiating mechanism, vessel maturation (stabilization) involves the recruitment of pericytes and smooth muscle cells to form the periendothelial layer.. (Modified from Conway EM et al: Molecular mechanisms of blood vessel growth. Cardiovasc Res 49:507, 2001.) * * Granulation tissue: Small, fleshy, beadlike protuberances, consisting of outgrowths of new capillaries, on the surface of a wound that is healing. * * * * * * * * * * * * * * * * Steps in wound healing by first intention (left) and second intention (right). Note large amounts of granulation tissue and wound contraction in healing by second intention. * Healing of skin ulcers. A, Pressure ulcer of the skin, commonly found in diabetic patients. The histology slides show B, a skin ulcer with a large gap between the edges of the lesion; C, a thin layer of epidermal reepithelialization and extensive granulation tissue formation in the dermis; and D, continuing reepithelialization of the epidermis and wound contraction. * * * HB-EGF, heparin-binding EGF; IL-1, interleukin 1; TNF, tumor necrosis factor; other abbreviations as given in Table 3- * * * * * * Peyronie was a god in old greece mythos. He had great, firm penis, but it could not be softing, so he was painful. In the modern medicine, Peyronie’s disease is fibrous spongiitis leading a firm penis for long time * * * * * * * * * * Figure 3-11 Liver regeneration after partial hepatectomy. A, The lobes of the liver of a rat (M, median; RL