妇产科学课件：13_2Endometrial Carcinoma 1.ppt

3. High efficiency progestin If progestin receptor is positive, the effective rate is about 80%. megestrol acetate, 500mg daily orally 4. chemotherapy ------ cancer of late stage; recurrent cancer cisplatin taxol summary Pathogenesis Pathology Staging Clinical Findings﹡ Diagnosis﹡ Differential Diagnosis Treatment﹡ The three tumors include The incidence of cancer is .it happens in postmenopause about 75% and in pre-menopause about 25 We divide two types Pathogenesis, We knew from these words , This type of disease related to estrogen levels and Another type of disease has nothing to do with estrogen We can see cancer full of whole uterine cavity ,include the left,,right ,and local Please refer to the book The tumor is beyond the scope of the uterus We can see what place lesions planting in the uterine cavity by hysteroscopy Age 58 , G2P0 Irregular bleeding for 2 months. Menopause at age 52. Past history: diabetes mellitus for 3 years. Case Report 1 of 3 common malignant tumors of female reproductive system General Consideration Endometrial carcinoma Cervical cancer Ovarian cancer 7% of all malignant tumors in women 20%~30% of malignant tumors in female genital system peak incidence at age 58 -- 61 75% postmenopause 25% pre-menopause ( 5% age 40 ) Pathogenesis Estrogen-dependent Endometriod adenocarcinoma prognosis is good Estrogen-independent Other kinds of pathological types prognosis is poor Risk factors 1. Estrogen stimulation (1) Exogenous estrogen stimulation estrogen replacement therapy tamoxifen (2) Endogenous estrogen stimulation polycystic ovary syndrome (PCOS) ovarian granulosa cell tumor（卵巢颗粒细胞肿瘤） Risk factors 2. Triple sign Diabetes Obesity Hypertension 3. infertility ， delayed menopause 4. Genetics factor family history of breast can