临床分离菌对司帕沙星的敏感性研究.doc

临床分离菌对司帕沙星的敏感性研究 中国抗生素杂志2000年第2期第25卷论著 作者：冯萍张慧琳吕晓菊渝汝佳周志强朱淑缓 单位：冯萍 张慧琳 吕晓菊 渝汝佳 周志强 朱淑缓(华西医科大学附属第一医院感染 科，成都610041) 关键词：司帕沙星；体外抗菌活性 摘 要 采用纸片法和琼脂平板稀释法测定了 196株临床分离菌对司帕沙星的敏感性， 并同洛美沙星、氧氟沙星、环丙沙星和依诺沙星进行比较。纸片法结果显示，细菌对司帕沙 星的敏感率最高，为97.45%；其次是环丙沙星(93.36%),氧氟沙星(92.85%),洛美沙星 (91.32%)；对依诺沙星的頌感率瑕低(84.69%)o革兰氏阳性菌对司帕沙星的敏感率略高于革 兰氏阴性菌，分别为100%和96.68%(P0.05)o金葡球菌、大肠埃希氏菌、铜绿假单胞菌和 不动杆菌対司帕沙星的敏感率分别为100%、94.12%、95.00%和88.89%。MIC测定结果表 明，司帕沙星对所有细菌的MIC均低于英它4种抗菌药物。抑制50%和90%的金徜球菌所 需的司帕沙星浓度为0.125和2mg/L,是其它药物1/4?1/16。对于肠杆菌科的细菌，司帕沙 星的MIC50和MIC90在0.5和4mg/L之间，是其它4种药物1/4?1/8倍。对于铜绿假屮胞 菌，司帕沙星的MIC50和MIC90与环丙沙星和依诺沙星相同，低于洛美沙星和氧氟沙星。 对不动杆菌的体外抗菌活性优于其它4种药物4?8倍。所有5种氟座诺酮药物对秒门氏菌 屈和其它肠杆菌均显示非常好的体外抗菌活性。MIC90在0.06?0.5mg/L之间。以上说明， 司帕沙星较洛美沙星、氧氟沙星、环丙沙星和依诺沙星具有更好的体外抗菌活性。 Study on susceptibility of clinical bacteria isolates to sparfloxacin Feng Ping, Zhang Huilin, Lu Xiaoju, Yu Rujia, Zhou Zhiqiang and Zhu Suyuan (Department of Infectious Disease, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041) ABSTRACT The susceptibility to sparfloxacin in 196 strains of clinical isolates was measured by Kirby-Bauer method and an agar dilution method, compared with lomefloxacin, ofloxacin, ciprofloxacin and enoxacin. From the result of Kirby-Bauer method, the rate of susceptibility to sparfloxacin was the highest, 9745%, followed by ciprofloxacin (93.36%) ofloxacin (92.85%), lomefloxacin (91.32%) and that to eno-xacin is the lowest, 84.69%. Gnim-positive bacteria was more sensitive than gram-negative isolates, the sensitive rate of the two kinds of bacteria were 100% and 96.68% (P0.05) respectively. The rate of sen-sitivity to sparfloxacin in S.aureus, E.coli, P.aeruginosa and Acinetobacter were 100%, 94.12%, 95% and 88.89% respectively. The agar dilution method result showed that MIC for 50% and 90% of S.aureus was 0.125 and 2mg/L; for En terobacte ri ace as 4 ?6 fold lower than that of other four fluroquinolones; the MIC50 and MIC90 were between 0.5 and 4mg/L, 4?8 fold lower than those of other fou