正常妊娠中晚期血脂系列指标变化探讨.doc

正常妊娠中晚期血脂系列指标变化的探讨 张铭王慧艳％，张一鸣马纹2 (1南京医科大学附属常州审妇幼保健院检验科，江苏常州213003； 2南京医科人学附属 常州审妇幼保健院产科，江苏常州213(X)3) 摘要 目的 观察并分析正常妊娠中晚期血脂代谢的特点。方法 选取孕24?28周平均年 龄(237±3.40)年龄在岁、孕_29?32周平均年龄(2 17±3.09)岁、更33?36周平均年 龄(27.63±3.16)岁、生37?41周平均年龄(27.47±2.96)岁4组共345例正常妊娠孕妇 作为研究对象具体具体数量？ 一般状况分布？,抽取空腹静脉血，测定总胆固醇(TC)、 甘油三脂(TG)、高密度脂蛋白胆固醇(IIDL-C)、低密度脂蛋白胆固醇(LDL-C) ＞载脂蛋 白 Al (ApoAl)、载脂蛋白 B (ApoB)、LP(a)、游离脂肪酸(NEFA),并计算 AP0A1/AP0B 比值。 结果妊娠中晚期血消TG与NEFA水平变化趋势一致，随孕周增加而上升，在分娩前达到最高 峰血清(/K0. 05):血清IIDL-C. AP0A1水平和AP0A1/AP0B变化趋势一致，随孕周增加而下降 (只0.05)； LDL-C和TC水平随孕周增加呈先上升后下降的趋势(A0. 001),在孕晩期37周前 达高峰；APOB. Lp(a)在孕中、晚期均变化不明显,4组的水平无明显差异(00.05)结论 正 常妊娠中晚期血脂代谢发生明显改变，备指标变化趋势不完全相同;应巫视妊娠中晩期孕妇 血脂水平检测。 关键词妊娠；血脂；代谢紊乱 中图分类号R446 文献标识码A The study of Invcstigating —serum lipid changes of normal pTcgnancy in the second and_ 聘譬監魏蠹行缩进…字third trimesters of normal pregnancy 聘譬監魏蠹行缩进…字 ZHANG Ming 1 , WANG Huiyan2*,ZHANG Yiming MA Wen2 (I .Department of Clinical Laboratory, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University,Changzhou 213003, Jiangsu ,China 2.Dcpartmcnt of obstetrics, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University,Changzhou 213003, Jiangsu ,China) [Abstract] Objective To investigating and analyze the characteristics of serum lipid metabolism in the second and third trimesters of normal 棊金项目：江苏省常州市科技规划项冃(c 亦通讯作者,E-mail: HYPERLINK mailto:zmzw0701@163.comzmzw0701@163.com pregnaney. Methods 345 Women of normal pregnancy in the second and third trimesters were recruited in groups?:? The lipid levels were measured , including total cholesterol (TC),triglyceride(TG), high-densi ty 1ipoprotein cholesterol (HDL-C) ,low-density lipoprotein cholesterol (LDL-C), apolipoprotein A 1 (ApoAl), apolipoprotein B(ApoB), lipoprotein(a), nonesterified fatty acids(NEFA). The ratio of ApoAl/ ApoB was calculated. Results The levels of serum TG and NEFA in the second and third trimesters rose with the increase of gestational weeksHge and reached th