细胞与分子免疫学infectionandimmunity-ok.ppt

? Bacterial flagellin ? Lipoteichoic acid from G+ bacteria ? Bacterial lipopolysaccharide (LPS) ? Peptidoglycan Pathogen-associated molecular pattern 病原相关分子模式（ PAMP ） ? Viruse nucleic acid : dsRNA or unmethylated CpG motifs Structure of Lipopolysaccharide ? Bacterial lipopolysaccharide (LPS) ----TLR 4 ? Viruse nucleic acid : dsRNA or unmethylated CpG motifs ? Membrane-bound PRRs ? Receptor kinases (discovered in plants) ? Toll-like receptors ? The mannose receptor ? Cytoplasmic PRRs ? NOD-like receptors (NLR) ? RNA Helicases ? Secreted PRRs ? Complement receptors ? Collectins (mannan-binding lectin) ? C-reactive protein ? lipid transferases ? peptidoglycan recognition proteins Pattern recognition receptors 模式识别受体 Receptor Ligand(s) Ligand location TLR 1 multiple triacyl lipopeptides Bacteria TLR 2 multiple glycolipids Bacteria multiple lipopeptides Bacteria multiple lipoproteins Bacteria lipoteichoic acid Bacteria HSP70 Host cells zymosan (Beta-glucan) Fungi Numerous others TLR 3 double-stranded RNA, poly I:C Viruses TLR 4 lipopolysaccharide Gram-negative bacteria several heat shock proteins Bacteria and host cells fibrinogen host cells heparan sulfate fragments host cells hyaluronic acid fragments host cells Numerous others TLR 5 flagellin Bacteria TLR 6 multiple diacyl lipopeptides Mycoplasma Receptor Ligand(s) Ligand location TLR 7 imidazoquinoline small synthetic compounds loxoribine (a guanosine analogue) bropirimine single-stranded RNA TLR 8 small synthetic compounds; single-stranded RNA TLR 9 unmethylated CpG Oligodeoxynucleotide DNA Bacteria TLR 10 unknown unknown TLR 11 Profilin Toxoplasma gondii TLR 12 unknown TLR 13 unknown TLR 15 unknown Salmonella enterica serovar Typhimurium ? 1.PAMP and Pattern recognition receptor ? 2.General features of immune responses to micro