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2021年考研英语阅读理解考前冲刺试题第四套 When Ellen M. Roche, 24, volunteered for the asthma experiment, she didnt expect to benefit from it——except for the $365 shed be paid. Unlike clinical trials, in which most patients hope that an experimental therapy will help them, this study was designed just to answer a basic question: how does the way a normal lung reacts to irritants shed light on how an asthmatic lung responds? To find out, scientists led by Dr. Alkis Togias of Johns Hopkins University had Roche and other healthy volunteers inhale a drug called hexamethonium. Almost immediately Roche began to cough and feel short of breath. Within weeks her lungs failed and her kidneys shut down. On June 2 Roche died——a death made more tragic by the possibility that it was preventable. Last week the federal Office for Human Research Protections (OHRP) ruled that Hopkinss system for protecting human subjects is so flawed that virtually all its U.S.-supported research had to stop. The worst part is that Hopkins, one of the nations premier medical institutions, is not alone. Two years ago the inspector general of the Department of Health and Human Services warned that the system safeguarding human subjects is in danger of a meltdown. The boards that review proposed studies are overburdened, understaffed and shot through with conflicts of interest. Oversight is so porous that no one knows how many people volunteer to be human guinea pigs (21 million a year is an educated guess), how many are hurt or how many die. “Thousands of deaths are never reported, and adverse events in the tens of thousands are not reported,” says Adil Shamoo, a member of the National Human Research Protections Advisory Committee and professor at the University of Maryland. Greg Koski, head of OHRP, has called the clinical-trials system “dysfunctional.” The OHRP findings on Hopkins are nothing short of devastating. After a three-day inspection last week, OHRP concluded that the Hopkins scientists failed to get inf
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