vit d缺乏性佝偻病双语2016.ppt

VitD’s Discovery 1650, Francis Glisson found Rickets common among the rich person 1822, reported: Rickets related to lack of sun exposure 1824,found: fish liver oil could treat Rickets 1918, a English man mistake for rickets caused by the lack of VitA 1921, was named VitD, the 4th Vit 1936, chemical characteristics of VitD ascertained Definition Where does Vitamin D come from? Why do we need Vitamin D? A main action of vitamin D is to help calcium and phosphorus in our diet to be absorbed from the gut. Increase renal tubular reabsorption of calcium phosphate, especially phosphorus bone calcium mobilization:release calcium from old bone, calcium deposites on osteoblast Calcium and phosphorus are needed to keep bones healthy and strong. In addition, vitamin D seems to be important for muscles and general health. There is also some evidence that vitamin D may also help to prevent other diseases such as cancer, diabetes and heart disease When/Why Vitamin D Deficiency Happen? Vitamin D deficiency means that there is not enough vitamin D in your body. Broadly speaking, this can occur in three situations: The body has an increased need for vitamin D grow too fast The body is unable to make enough vitamin D gastrointestinal?tract disease, hepatic and gall diseases, medicine,etc. Not enough vitamin D is being taken mother, food, sunlight Causes of rickets ---lack of Vitamin D Sunlight: children now tend to spend less time outdoors.日照不足 Food: breast feeding食物中补充不足 Need more: grow rapidly需要增加,生长速度快 Mother’s store of Vit D: twins, preterm围生期不足 Absorption problems :diseases, drugs: diarrhea Inflammatory bowel disease Cystic fibrosis Kidney problems疾病影响 Risk Factors Age：3 -36 months Dark skin Northern latitudes Premature birth Anti-seizure medications Exclusive breast-feeding Diagnosis:Clinical Stages Early stage/Initial stage(初期/早期）:3-6m, increased nerve excitability(crying), pressure alopecia Active stage