参考文稿文本遗传学遗传chapter10 genomes and proteomes.pdf

Chapter 10 Genomes and Proteomes Genomes and Proteomes Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 10-1 Outline of Chapter 10 Outline of Chapter 10  Challenges and strategies of genome analysis  Challenges and strategies of genome analysis  Genome size  Genome size  Features to be analyzed  Features to be analyzed  Problems with DNA polymorphisms  Problems with DNA polymorphisms  Development of whole-genome maps  Development of whole-genome maps  Insights emerging from complete genome sequencing  Insights emerging from complete genome sequencing  Number and type of genes  Number and type of genes  Extent of repeated sequences  Extent of repeated sequences  Genome organization and structure  Genome organization and structure  Evolution by lateral gene transfer  Evolution by lateral gene transfer  Social and ethical issues with human genome  Social and ethical issues with human genome sequencing sequencing Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 10-2 Genome and genomics Genome and genomics  Genome: The entire genetic information in a particular cell or organism.  Genomics: The study of whole genomes. It dedicated to the development and lication of more effective m ing, sequencing, and computational tools.  Genomicist: A expert of genomics. Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 10-3 Techniques for m ing and sequencing Techniques for m ing and sequencing  Cloning  Cloning  Library of DNA fragments 500 – 1,000,000 bp  Library of DNA fragments 500 – 1,000,000 bp