文稿完整资料遗传学遗传chapter11 genome-wide variation and trait analysis.pdfVIP

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文稿完整资料遗传学遗传chapter11 genome-wide variation and trait analysis.pdf

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Chapter 11 Genome-Wide Variation Genome-Wide Variation and Trait Analysis and Trait Analysis Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-1 Outline of Chapter 11 Outline of Chapter 11  Five classes of DNA variation serves as the  Five classes of DNA variation serves as the basis for direct detection of genotype basis for direct detection of genotype  Detection of DNA polymorphisms by  Detection of DNA polymorphisms by hybridization, gel electrophoresis, PCR, hybridization, gel electrophoresis, PCR, microarrays, and sequencing microarrays, and sequencing  Positional cloning of genes  Positional cloning of genes Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-2 Extension to Mendelian inition of locus and allele in the post-genome era  Locus – a designated location anywhere on a  Locus – a designated location anywhere on a chromosome. chromosome.  Allele – one of two or more a rnative DNA  Allele – one of two or more a rnative DNA sequences found at a locus – either coding or sequences found at a locus – either coding or noncoding. noncoding. Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-3 Members of the same species show enormous Members of the same species show enormous sequence variation in their genomes sequence variation in their genomes J. Craig Venter James Watson Figure 11.2 Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-4  1 in 1000 bp difference in any two randomly  1 in 1000 bp difference in any two randomly chosen humans. chosen humans.  3 mi