抗磷脂酶a2受体抗体与特发性膜性肾病..ppt

抗磷脂酶A2受体抗体与特发性膜性肾病;研究背景 研究方法 结论;研究背景;Beck Jr LH, et al. N Engl J Med 2009; 361: 11;Glassock RJ. N Engl J Med,2009,361: 81;病例选择;病例选择;;研究结果; Detection of anti-PLA2R in idiopathic MN;Recognition of idiopathic MN serum with deglycosylated PLA2R;The prevalence of anti-PLA2R in idiopathic MN and secondary MN; There was an absence of immunologic disease activity at the time when their serum was sampled, despite proteinuria.;Low titer of anti-PLA2R in negative idiopathic MN;Association of anti-PLA2R with disease activity;Anti-PLA2R in IMN and IMN with complete remission;结 论;致 谢;IgG4 in a glomerulus of a patient with tumor-MN but without circulating anti-PLA2R antibodies. Bright IgG4 in a glomerulus of a patient with tumor-MN and circulating anti-PLA2R antibodies. ;All three patients with Anti-PLA2R : persistent or relapse of proteinuria despite resection of the tumor. In those patients without anti-PLA2R: 2 patients: complete remission of the proteinuria after tumor resection; 3 patients died of cancer; The remaining 2 patients had persistent proteinuria without tumor resection.