2020+临床实践指南：遗传性弥漫性胃癌（更新版）.pdfVIP

Policy Review Hereditary diffuse gastric cancer: updated clinical practice guidelines Vanessa R Blair, Maybelle McLeod, Fátima Carneiro, Daniel G Coit, Johanna L D’Addario, Jolanda M van Dieren, Kirsty L Harris, Nicoline Hoogerbrugge, Carla Oliveira, Rachel S van der Post, Julie Arnold, Patrick R Benusiglio, Tanya M Bisseling, Alex Boussioutas, Annemieke Cats, Amanda Charlton, Karen E Chelcun Schreiber, Jeremy L Davis, Massimiliano di Pietro, Rebecca C Fitzgerald, James M Ford, Kimberley Gamet, Irene Gullo, Richard H Hardwick, David G Huntsman, Pardeep Kaurah, Sonia S Kupfer, Andrew Latchford, Paul F Mansfield, Takeshi Nakajima, Susan Parry, Jeremy Rossaak, Haruhiko Sugimura, Magali Svrcek, Marc Tischkowitz, Toshikazu Ushijima, Hidetaka Yamada, Han-Kwang Yang, Adrian Claydon, Joana Figueiredo, Karyn Paringatai, Raquel Seruca, Nicola Bougen-Zhukov, Tom Brew, Simone Busija, Patricia Carneiro, Lynn DeGregorio, Helen Fisher, Erin Gardner, Tanis D Godwin, Katharine N Holm, Bostjan Humar, Caroline J Lintott, Elizabeth C Monroe, Mark D Muller, Enrique Norero, Yasmin Nouri, Joana Paredes, João M Sanches, Emily Schulpen, Ana S Ribeiro, Andrew Sporle, James Whitworth, Liying Zhang, Anthony E Reeve, Parry Guilford Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high Lancet Oncol 2020; 21: e386–97 prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations Department of Surgery, in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with University of Auckland, HDGC. In this Policy Review, we