注射部位肉瘤.pdf

Heather Robles, DVM DACVIM (Oncology) • Injection Site Sarcomas/Vaccine Associated Sarcomas / • Soft Tissue Sarcomas • Feline Sarcoma Virus • Epidemiology and risk factors • Pathology • Diagnosis and work up • Treatment • Prognosis • Prevention • Take home message ! • Rare recombination of FeLV DNA provirus cat proto- oncogenes. FeLV DNA • Multiple sarcomas arise along the torso and possibly the rest of the body. • Cats may develop antibodies to FOCMA. RNA – Regression of tumors – Without it, cats die quickly • Mid 1980s 1980 – Killed rabies vaccine approved – Killed FeLV vaccine developed FeLV • 1987 – Pennsylvania passed a law requiring cats to be vaccinated against rabies • 1991 – The first paper published linking vaccines and sarcomas by Hendrick and Goldschmidt HendrickGoldschmidt • FeLV and Rabies virus vaccines FeLV • Incidence increases with the number of vaccines given in one area simultaneously. • Incidence of ISS/VAS – 1/1000 to 1/10,000 • Incidence of STS – 20/100,000 • Tumor development – 4 weeks to 10 years 410 • Etiologies – Rabies vaccine – FeLV vaccine FeLV – Other vaccines – Other injection sites Injection/ Vaccination Inflammatory mediators Uncontrolled fibroblast and myofibroblast proliferation Transition zone and microscopic sarcomas