（英）损伤、失调以及丝聚合蛋白缺失通过角质化细胞释放IL--1α导致皮肤炎症.pdfVIP

Atopic dermatitis and inflammatory skin disease Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release Nathan K. Archer, PhD,a Jay-Hyun Jo, PhD,b Steven K. Lee, BS,a Dongwon Kim, PhD,a Barbara Smith, MS,c Roger V. Ortines, MS,a Yu Wang, PhD,a Mark C. Marchitto, MD,a Advaitaa Ravipati, MS,a Shuting S. Cai,a Carly A. Dillen, PhD,a Haiyun Liu, PhD,a Robert J. Miller, MS,a Alyssa G. Ashbaugh, BS,a Angad S. Uppal,a Michiko K. Oyoshi, MD,d Nidhi Malhotra, PhD,d Sabine Hoff, PhD,d,e Luis A. Garza, MD, PhD,a Heidi H. Kong, MD,b Julia A. Segre, PhD,f Raif S. Geha, MD,d and Lloyd S. Miller, MD, PhDa,g,h,i Baltimore and Bethesda, Md, Boston, Mass, and Berlin, Germany GRAPHICAL ABSTRACT a c g 8UL 1TR000170; to M.K.O.), and the Boston Children’s Hospital Pediatric Associates From the Department of Dermatology, the Department of Cell Biology, the h Award (to M.K.O.). Department of Medicine, Division of Infectious Diseases, and the Department of Disclosure of potential conflict of interest: L. S. Miller has received grant support from Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore; b MedImmune, Pfizer, Regeneron Pharmaceuticals, Moderna Therapeutics, and the Dermatology Branch, Center for Cancer Research, National Cancer Institute, and fthe Microbial Genomics Section, Translational and Functional Genomics Branch, Boehringer Ingelheim; is on the scientific advisory board f