（英）甘草甜素对树突状细胞成熟和T细胞刺激活性的影响.pdfVIP

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（英）甘草甜素对树突状细胞成熟和T细胞刺激活性的影响.pdf

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Cellular Immunology 280 (2012) 44–49 Contents lists available at SciVerse ScienceDirect Cellular Immunology journal homepage: /locate/ycimm The effect of glycyrrhizin on maturation and T cell stimulating activity of dendritic cells Narges Bordbar a, Mohammad Hossein Karimi d, Zahra Amirghofran a,b,c,⇑ a Department of Immunology, Shiraz University of Medical Science, Shiraz, Iran b Autoimmune Diseases Research Center, Shiraz University of Medical Science, Shiraz, Iran c Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Science, Shiraz, Iran d Shiraz Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran a r t i c l e i n f o a b s t r a c t Article history: Glycyrrhizin (GL), a main component of the plant Glycyrrhiza glabra has shown various immunomodula- Received 2 October 2012 tory activities that can interfere with immune responses by targeting the dendritic cells (DCs). In this Accepted 9 November 2012 study, the effects of GL on the maturation and function of mouse splenic DCs was investigated. The results Available online 1 December 2012 of ﬂow cytometry analysis showed that GL was able to up-regulate the expression of CD40, CD86 and MHC-II maturation markers on DCs. This component increased the production of IL-12 by these cells. Keywords: The capacity of treated DCs to stimulate allogenic T cells and sec