基于国家专利的中药复方治疗化学性肝损伤用药规律研究.docx

PAGE PAGE 1 基于国家专利的中药复方治疗化学性肝损伤用药规律研究 　　 　　樊建 栾宁 赵曙宇 张利那 陈大忠 王艳宏 　　 　　 　　 　　摘要：目的 分析國家专利治疗化学性肝损伤的组方用药规律，为新药研发及相关专利的申请提供参考。方法 以国家知识产权局中国专利公布公告网站收录的授权专利为资料来源，使用Microsoft Excel 2021建立数据库，对中药频次与分类进行统计分析;采用SPSS Statistic 21.0和SPSS Modeler 15.0对高频中药（频次≥10）进行性味归经分析、系统聚类分析、关联度与网络分析。结果 纳入专利100项，涉及中药186味，以葛根最为常见;高频中药15味，药味以甘为主，药性以温、平为主，多归脾、肝经;聚类分析得到7组中药组合;二项、三项和四项关联规则分别为6、24、2项，各项组合分别为6、16、2项;核心药物为葛根、五味子、丹参、甘草、山楂、枸杞子、黄芪、柴胡、姜黄和枳椇子。结论 中药复方治疗化学性肝损伤常用补虚、解表、化瘀、活血、渗湿及利水药;临证多采用疏肝理气之剂，适当伍以柔润之品。 　　关键词：化学性肝损伤;专利;用药规律;聚类分析;关联规则 　　中图分类号：R259.95;R2-05 文献标识码：A 文章编号：1005-5304（2020）04-0092-06 　　DOI：10.3969/j.issn.1005-5304.202106016 　　Study on Medication Laws of TCM Compounds for Treatment of 　　Chemical Liver Injury Based on National Patent 　　FAN Jian， LUAN Ning， ZHAO Shuyu， ZHANG Lina， CHEN Dazhong， WANG Yanhong 　　Heilongjiang University of Chinese Medicine， Harbin 150040， China 　　Abstract： Objective To analyze the medication laws of TCM prescriptions of treatment for chemical liver injury; To provide references for the development and research of new drugs and application of related patents. Methods Authorized patents recorded by the national patent database China Patent Announcement Website were taken as the data source. Microsoft Excel 2021 was used to establish a database and analyze the frequency of Chinese materia medica and the classification; SPSS Statistic 21.0 and SPSS Modeler 15.0 were used to analyze properties， tastes， and meridian tropism of high-frequency Chinese materia medica （frequency≥10）， and hierarchical cluster analysis， correlation degree and network analysis were conducted. Results Totally 100 patents were included， involving 186 kinds of Chinese materia medica， Puerariae Lobatae Radix with the highest frequency. There were 15 kinds of high-frequency Chinese materia medica; the taste was mainly sweet， the properties were mostly warm and flat， and mostly attributive to the spleen and liver meridians. 7 groups of TCM combinations were obtained by cluster ana