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1. Taken together, our data provide new mechanistic insights into possible endogenous
signaling metastatic signaling pathways involved in maintaining proliferation and
migration of breast cancer cells.
2. We sought to determine whether seliciclib (CYC202, R‐roscovitine) could increase the
antitumor effects of doxorubicin, with no increase in toxicity, in an MCF7 breast
cancer xenograft model.
3. MIB1 (ki67) immunohistochemistry demonstrated reduced proliferation with
treatment.
4. Survivin embodies these properties, and
5. Moreover, in pre‐clinical bladder tumor models, inhibition of Survivin expression
and/or function has been shown to impede tumor cell proliferation, and markedly
induce spontaneous or chemotherapy induced apoptosis
6. The efficacy of mainstay cancer therapies, cytotoxics and radiation, has reached a
plateau in the treatment of many cancers, and there is an urgent sense that
improvements must now come from fresh approaches.
7. Median age was 62 years with a range of 40‐74 years.
8. splice variants might function in effect as dominant negatives so that their expression
might concurrent with survivin.
9. There is a hypothesis that XXX
10. The absence of in vivo data on this point has now been remedied with a paper in this
issue of the JCI by Altieri and colleagues.
11. Thus, this raises an interesting question whether...
12. raising the possibility that most, if not all, tumors express...
13. The levels of p21 and p27 increased after treatment with doxorubicin or seliciclib alone
or in combination, compared to untreated controls.
14. In contrast, it is abundantly expressed in a wide variety of malignant tissues.
15. On the contrary,...
1
16. By contrast, a good title will attract the relevant researchers and increase the number
of citations you receive
17. We have found that the human breast can
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