100ta 4-羟基苯乙酮车间设计.docVIP

本科毕业设计说明书 × 100t/a 4-羟基苯乙酮车间设计 × 专 业 班 级 学 号 学生姓名 指导教师 完成日期 100t/a 4-羟基苯乙酮车间设计 盐城工学院本科毕业设计说明书（2021） PAGE PAGE IV PAGE V PAGE V 100t/a 4-羟基苯乙酮车间设计 摘 要：本次设计是年产100吨4-羟基苯乙酮车间设计，4-羟基苯乙酮是重要的药物中间体和利胆药。通过比较目前常用的几种合成方式，选择一条最佳的合成工艺路线——原料选择苯酚和乙酸酐，发生酯化反应生成乙酸苯酯，再通过Fries重排，以无水三氯化铝作为催化剂得到最终产物4-羟基苯乙酮；对各工段进行物料衡算和能量衡算，通过已获得的工艺计算结果进行设备的挑选和选择，主要是酯化、Fries重排和精制三个工序的反应釜的选择；对主要合成过程进行带控制点的工艺流程图的设计，对4-羟基苯乙酮的生产车间进行布置和设计；根据实际情况分析生产过程的环境问题和安全问题，并提出措施；最后使用Auto CAD软件绘制出带控制点的工艺流程图、车间平面布置图等，对设计进行总结和复核从而完成本次设计。 关键词： 车间设计；4-羟基苯乙酮；酯化反应；Fires重排  Workshop design of 100t/a 4-hydroxyacetophenone abstract: This design is a workshop design that produces 100 tons of 4-hydroxyacetophenone annually. 4-Hydroxyacetophenone is an important pharmaceutical intermediate and bile secretagogue. By comparing several synthesis methods commonly used at present, an optimal synthesis process route was selected. The raw materials were phenol and acetic anhydride. The esterification reaction first produced phenyl acetate, and then the final product 4-hydroxyacetophenone was obtained through Fries rearrangement reaction. Anhydrous aluminum trichloride was used as catalyst; Perform the material and energy balance calculations for the various sections and select the equipment based on the obtained process calculation results, It is mainly the selection of reaction kettle in three processes: esterification, Fries rearrangement and refining; Perform the control points of the main synthesis process. Process flow chart design, manufacturing workshop layout and design, and pipeline calculation and design; Analyze environmental and safety issues in the production process according to the actual situation and take measures; Finally, use AutoCAD draws process flowcharts with control points, workshop floor plans, etc., summarizes and reviews the design, and completes the design. Keywords: Workshop design; 4-hydroxyacetophenone; Esterification reaction; Fires rearrangement  目 录 TOC \o 1-3 \h \u