病理解剖1班11肺结核.pptx

Infectious disease;§1 Introduction; Acute: Fibrinous→bacillary dysentery; Suppurative→suppurative meningitis Chronic: Granulomatous inflammation TB, leprosy;§2 Tuberculosis;The characteristic lesion : Formation of tubercle Central caseous necrosis. ; 2. Classification Pulmonary TB primary TB secondary TB Extrapulmonary TB intestinal TB tuberculous meningitis tuberculous peritonitis TB of bone , joint TB of LN TB of urinary S genital S;二. Etiology and Pathogenesis;(2) Routes of infection ① Respiratory tract: main direct person to person transmission of sneeze, cough droplets with organisms (1-20 bacteria/droplet);② Alimentary tract: less; contaminated milk by bovine type ③ Local skin lesion: rare ;2. Pathogenic substance of mycobacterium tuberculosis ① Lipid: ⅰ Related to pathogenicity, especially glycolipid cord factor: wax D: cause severe allergy→ tissue damage;ⅱ Protect bacillary bodies from digestion of macrophage inhibit bacteria combine with lysosome, the bacteria can survive ⅲ Phosphatide change the macrophage into epithelioid cells in the inflammatory focus;② Polysaccharide lipoarabinomannan inhibit activity of macrophage secreting TNF-α: necrosis IL-10: inhibit cell immune;③ Complement: Promoting phagocytosis ④ Protein:Heat-shock protein Ag autoinmmune reaction;3. Pathogenesis Cell immunity