康斯特保护液对紫绀型先天性心脏病未成熟心肌保护效果的研究临床医学.doc

康斯特保护液对紫绀型先天性心脏病未成熟心肌保护效果的研究临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：康斯特保护液对紫绀型先天性心脏病未成熟心肌保护效果的研究临床医学 2 1 资料与方法 3 0级(0分):线粒体结构正常，可见保存完好的线粒体颗粒； 4 Ⅰ级(1分):线粒体结构基本正常，线粒体颗粒丢失； 4 Ⅱ级(2分):线粒体肿胀，基质透明; 4 Ⅲ级(3分):线粒体嵴断裂，基质凝结; 4 2 结 果 5 3 讨 论 5 文2：紫绀型先天性心脏病临床病理分析 7 1 资料与方法 8 2 结 果 8 3 讨 论 10 参考文摘引言： 13 原创性声明（模板） 14 文章致谢（模板） 15 正文 康斯特保护液对紫绀型先天性心脏病未成熟心肌保护效果的研究临床医学 文1：康斯特保护液对紫绀型先天性心脏病未成熟心肌保护效果的研究临床医学 Abstract: OBJECTIVE To study the protective effects of HTK solution on immature myocardium in cardiac operation. METHODS 40 infants weighted 8-15 kg with cyanotic congenital heart disease and low saturation of blood oxygen (80%) wererandomly divided into ST. Thomas Ⅱsolution group (group A) and HTK (group B). The diagnosis of patients included tetralogy of Fallot (TOF), double outlet right ventricle (DORV), and single ventricle. Blood sample were collected from coronary sinus after anesthesia induction and 3 min after aorta clamp off to measure the serum level of cadiac troponin I (cTnI), creative kinase MB (CKMB), and lactate dehydrogenase (LDH). Clinical paramete including the auto-resuscitation ratio, inotropic support requirement, mechanical ventilation duration, and the stay time in the inteive care unit were recored. Ejection fraction (EF) was measured preperatively. Myocardial tissue was taken from the atrium to perform electronic microscopic examination. RESULTS The level of CKMB, LDH and cTnI in group B were lower than that in group A. The clinical paramete, the EF, and the results of electronic microscope showed that the myocardial damage in group B were less than that in group A. CONCLUSION The protective effects of HTK solution on immature myocardial in infants with cyanotic congenital heart disease is obviously better than solution. Key words： Cadioplegia; Myocardial protection;Cyanosed congenital heart disease;Infants 目前国内临床上广泛应用的心肌保护液仍为ST. Thomas液，其对婴幼儿未成熟心肌的保护效果尚未十分肯定。紫绀型未成熟心肌就其生理特点上与成熟心肌、健康未成熟心肌都有很大的区别，这就决定了其心肌保护有其本身的特