高等有机合成(全套课件).ppt

高等有机合成;绪;一、有机合成的历史回忆;2. ;2;3. ;4.;?;5. K. C. Nicolaou S. L. Schreiber;二、有机合成化学的开展趋势;N;?;?;2. ;?;?;四、重要参考书及期刊;?;五、课程安排;Chapter 2 ;一、;二、影响反响的主要因素;b.;c. ;d. ;三、烷基化反响;Example 2;Example 3;2. ;Example 2;3. ;Example 1;Example 2;Example 3;Example 4;4. ;Example 2;Example 3;5. ;MeO;6. ;Example 1;?;?;酸性条件;?;Example 1;7. ;?;扩展：;利用;?;Example;8. ;Example 2 ;Example 3 1, 3 ;Example 4 ;四、缩合反响;1.;2) ;Example 1;?;b. E-enolates;?;?;?;Metood 2 Preformed Boron Enolates;a. Z-enolate Preparation and Reactions;b. E-enolate Preparation and Reactions;-;c. Examples of more recent methods to control boron enolate geometry;Aldol Condensation with Chiral Enolates;?;?;Metood 3 Acid-Catalysed Directed Aldol Reactions;3) ;O;O;Catalytic Asymmetric Synthesis of anti-1,2-Diols;Proline-Catalyzed Asymmetric Aldol Reactions between;The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes;Novel Small Organic Molecules for a Highly ;2. Michael Addition Reaction;?;?;X;Me;The First Enantioselective Organocatalytic Mukaiyama-Michael Reaction: ;O;3. Mannich Reaction;Example 1;?;?;The Direct Catalytic Asymmetric;O;The Direct and Enantioselective, One-Pot, Three-;Three-component Mannich reaction with various acceptor aldehydes;Three-component Mannich reaction with various donor aldehydes.;4. Claisen Condensation;?;?;5. Dickmann Condensation;Chapter 3 ;I. The Synthetic Methods of Alklenes ;2. Pyrolytic syn eliminations;C;3. Wittig and related reactions ;?;Representative Examples ;Example 3;?;?;?;?;Influence of solvent on the selectivity;?;?;-;?;-Hindered phosphonates and hindered aldehydes increase E-selectivity ( trans).;-;?;-;?;-;4. The Tebbe Reaction and Related Titanium-stabilized Methylenations;-;5. Sulphoxide-sulphenate rearragement: Synthesis of allyl alcohols;Example;6. Alkenes from sulphones;-;-;7. Decarboxylation of ;Example 2;RCH;8. Stereoselective synthesis of tri-;?;Example;Method 2;H;9. Oxidative decarboxylation of carboxylic acids ;Example 2;10. Alkenes f