老年膝关节置换术患者应用帕瑞昔布钠术后早期认知功能的临床分析（临床医学论文资料）.docVIP

老年膝关节置换术患者应用帕瑞昔布钠术后早期认知功能的临床分析（临床医学论文资料） 文档信息 ： 文档作为关于“医学心理学”中“骨科学”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文6079字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：老年膝关节置换术患者应用帕瑞昔布钠术后早期认知功能的临床分析 2 1 资料与方法 3 2 结果 5 3 讨论 5 文2：不同麻醉方式对老年膝关节置换术患者围术期凝血功能的影响 6 1 资料与方法 6 2 结 果 7 3 讨 论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 10 正文 老年膝关节置换术患者应用帕瑞昔布钠术后早期认知功能的临床分析（临床医学论文资料） 文1：老年膝关节置换术患者应用帕瑞昔布钠术后早期认知功能的临床分析 The Clinical Analysis of the Postoperative Early Cognitive Function of Elderly Patients Using Celebrex Sodium in Knee Arthroplasty ZHANG Yunzhi Department of Anesthesiology， The People’s Hospital of Liuyang， Liuyang， Hunan Province， 410300， China [Abstract] Objective To investigate the effect of parecoxib sodium applied to elderly knee arthroplasty on the postoperative early cognitive function of the patients. Methods 60 elderly patients underwent selective knee arthroplasty in our hospital from January 2010 to January 2013 were selected and randomly divided into the observation group and the control group. The observation group were given parecoxib sodium 40mg before the induction of anesthesia and 12h after the operation， respectively， while the control group were given commeurable % sodium chloride solution. The IL-6， TNF-α and incidence of POCD of two groups of patients were compared. Results After the operation， the IL-6 and TNF-α levels of both groups of patients were significantly increased， compared with those before the induction of anesthesia， . Conclusion The application of parecoxib sodium in elderly knee arthroplasty can significantly reduce the release of early inflammatory cytokines in patients after surgery， but it does not reduce the incidence of postoperative POCD。 [Key words] Knee arthroplasty； Parecoxib sodium； Early cognitive function； Effect [作者简介] 张运芝（），男，湖南浏阳人，本科，副主任医师，研究方向：临床麻醉。 术后认知功能障碍（POCD）是指手术后出现的注意力、关注、学习和解决问题等认知功能损害证候群，对于老年患者量讲，较大型手术会增加POCD的发生率，且目前有研究表明POCD的发生与中枢炎症反应有关[1]。帕瑞昔布钠为新型的非甾体类抗炎药物，术前给予帕瑞昔布钠的应