Tiam1与PCNA在胃癌中的表达及其临床意义（临床医学论文资料）.doc

Tiam1与PCNA在胃癌中的表达及其临床意义（临床医学论文资料） 文档信息 ： 文档作为关于“医学心理学”中“肿瘤学”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文8663字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：Tiam1与PCNA在胃癌中的表达及其临床意义 2 1 资料和方法 3 2 结果 4 3 讨论 6 文2：PTEN和PCNA在胃癌中的表达及其临床意义 7 1 材料与方法 7 2 结果 8 3 讨论 9 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 Tiam1与PCNA在胃癌中的表达及其临床意义（临床医学论文资料） 文1：Tiam1与PCNA在胃癌中的表达及其临床意义 Expressio of Tiam 1 and proliferating cell nuclear antigen in gastric cancer and their clinical significance ZHU Jinming， YU Peiwu， ZHAO Yongliang. Department of General Surgery， General Hospital of Jinan Military Command， Jinan 250031， China 【Abstract】 Objective To observe expression of T lymphoma invasion and metastasis inducing factor 1 (Tiam 1) and proliferating cell nuclear antigen (PCNA) in gastric cancer and investigate their relatiohip with clinicopathological paramete. Methods The expressio of Tiam 1 and PCNA in cancer tissues and normal gastric mucosa of 60 cases with gastric cancer were detected by immunohistochemistry method. Results ①Staining of Tiam 1 protein was negative in normal gastric mucosa but positive in gastric cancer (47/60， %)， with significantly statistical difference (P ). ②PCNA labeling index (LI) in gastric cancer was ± that was significantly higher than ± in normal gastric mucosa (P ). ③Both expressio of Tiam 1 and PCNA were associated with the differentiation degree， invasive depth， TNM stage and lymph node metastasis of gastric cancer (P ) but not with sex and age of cases as well as primary pathological site or size of the cancer foci (P ). ④ PCNA LI in cases with positive staining of Tiam 1 was significantly higher than that in cases with negative staining of Tiam 1 (P ). Conclusio Upregulated expressio of Tiam 1 and PCNA are closely correlated with the invasion and metastasis of gastric cancer. Combined detection of Tiam 1 and PCNA is helpful for estimating the biological behavior of gastric cancer。 【Key words】 Gastric ca