基因及功能——精选推荐.pdfVIP

基因及功能 PAX6 （paired box 6） Function: Transcription factor with important functions in the development of the eye, nose, central nervous system andpancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 inbinding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of theventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to functionas a molecular switch that specifies target genes SOX2 （SRY (sex determining region Y)-box 2） Function: T ranscription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stemcell pluripotency. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) Nestin Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) Wt1 （Wilms tumor 1） Function: T ranscription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform- specific: isoforms lacking the KTS motif may act as transcription factors. Iso