Agilent Comparing Collision Reaction Cell Modes for the Measurement of Interfered Analytes in Complex Matrices using the Agilent 7700 Series ICP-MS 说明书用户手册.PDF

Comparing Collision/Reaction Cell Modes for the Measurement of Interfered Analytes in Complex Matrices using the Agilent 7700 Series ICP-MS Technical Overview Abstract Inductively coupled plasma mass spectrometry (ICP-MS) is a key analytical tool in many laboratories. It is used for elemental determinations across a wide range of analyses, including environmental, semiconductor, food safety, geological, chemical, petrochemical, nuclear, clinical, forensic, and research applications. Since the early publications during the development of ICP-MS, it has been apparent that one of the key limitations of the technique was the presence of molecular ions that overlap the preferred isotopes of several analytes. These molecular ions are typically called poly- atomic ions, and are derived from combinations of the elements present in the plas- ma, the solvent and the sample matrix. Strategies for reducing, removing or correcting for these polyatomic interferences vary, but most of the emphasis over the past 10 years has been on using collision/reaction cell (CRC) technology to selectively reduce the transmission of the interfering ions, thereby reducing the contribution of the interference at the analyte mass. Many publications have presented methods where a specific reaction gas is used to separate single, known interferences from single analyte isotopes. While this is of undoubted academic interest, the removal of a single, known interference from a single analyte is not relevant for the majority of real applications, where ICP-MS is used to determine multiple analytes in a range of complex and unknown sample matrices. This study compared no gas, reaction and collision modes for the measure- ment of multiple interfered analytes in the complex and variable matrices that are typi- cally analyzed in many laboratories. The data demonstrate the superior performance achieved with helium (He) collision mode in the 3rd generation Octopole Reaction Sys