Aldose-Reductase-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Aldose Reductase   Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney. Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it. www.MedChemE 1 Aldose Reductase Inhibitors 6-Methoxytricin AKR1B10-IN-1 Cat. No.: HY-N6883 Cat. No.: HY-139696 6-Methoxytricin (Compound 6) is an flavonoid AKR1B10-IN-1 is a potent inhibitor of AKR1B10 isolated from Artemisia iwayomogi. (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer