AMPK-Activators-Modulators-生命科学试剂-MedChemExpress.pdf

AMPK AMP-activated protein kinase AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria. www.MedChemE 1 AMPK Inhibitors Activators 10Z-Hymenialdisine 3α-Hydroxymogrol ((Z)-Hymenialdisine; Hymenialdisine) Cat. No.: HY-N6794 Cat. No.: HY-N6913 10Z-Hymenialdisine ((Z)-Hymenialdisine) is a 3α-Hydroxymogrol is a triterpenoid isolated from natural bioactive pyrrole alkaloid. Siraitia grosvenorii Swingle, acts as a potent 10Z-Hymenialdisine is a pan kinase inhibitor, and AMPK activator, and enhances AMPK has anticancer activities. phosphorylation. Purity: 98% Purity: 98.47% Clinical Data: No Development Reported