Angiotensin-converting-Enzyme-ACE-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Angiotensin-converting Enzyme (ACE)   Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure. www.MedChemE 1 Angiotensin-converting Enzyme (ACE) Inhibitors Activators (R)-MLN-4760 AD011 Cat. No.: HY-19414A Cat. No.: HY-143886 (R)-MLN-4760, the R-enantiomer of MLN-4760, is an AD011 is a dual inhibitor of cACE/ NEP. AD011 is ACE2 inhibitor, with an IC50 of 8.4 μM. synthesized based on the previously reported (R)-MLN-4760 is the less