Adenylate-Cyclase-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Adenylate Cyclase Adenylyl cyclase Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC. Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9. www.MedChemE 1 Adenylate Cyclase Inhibitors, Antagonists Activators 2,5-Dideoxyadenosine AC1-IN-1 Cat. No.: HY-135878 Cat. No.: HY-145830 2,5-Dideoxyadenosine is a potent and AC1-IN-1 is a potent and selective Adenylyl cyclase non-competitive adenylyl cyclase inhibitor via type 1 (AC1) inhibitor with an IC50 of 0.54 µM. binding the P-site with an IC50 of 3 µM . AC1-IN-1 displays modest antiallodynic effects in 2,5-Dideoxyadenosine is a nucleoside an