Amyloid-β-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Amyloid-β β-amyloid peptide; Aβ; Abeta Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimers disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction. www.MedChemE 1 Amyloid-β Inhibitors, Agonists, Antagonists, Activators Chemicals (R)-(+)-Anatabine 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 Cat. No.: HY-126047B Cat. No.: HY-W013425S (R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist. Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Purity: 98% Purity: 98% Clinical Data: No Development Reported Clinical