MCHR1-GPR24-Antagonists-Modulators-生命科学试剂-MedChemExpress.pdf

MCHR1 (GPR24) Melanin concentrating hormone receptor 1 MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, is a class A G-protein-coupled receptor (GPCR). MCHR1 has received considerable attention, as potent and selective antagonists acting at that receptor display anxiolytic, antidepressant and/or anorectic properties. MCHR1 is the sole receptor expressed in rodents and couples to G and G proteins. i q MCH is a ubiquitous vertebrate neuropeptide predominantly synthesized by neurons of the diencephalon that can act through two G protein-coupled receptors, called MCHR1 and MCHR2. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. www.MedChemE 1 MCHR1 (GPR24) Inhibitors, Agonists Antagonists Ac-hMCH(6-16)-NH2 ALB-127158(a) Cat. No.: HY-P3155 Cat. No.: HY-111398 Ac-hMCH(6-16)-NH2 binds to and activates equally ALB-127158(a) is a potent and selective melanin well both human MCH receptors present in the concentrating hormone 1 (MCH ) receptor