Melatonin-Receptor-Agonists-Modulators-生命科学试剂-MedChemExpress.pdf

Melatonin Receptor   Melatonin receptors belong to the G protein-coupled receptor superfamily, which preferentially couple to Gαi/o proteins. The melatonin receptor subfamily is composed of three members in mammals: MT and MT , which are both binding to the 1 2 neurohormone melatonin with high affinity, and GPR50, which shows high sequence homology to MT and MT but does not bind 1 2 to melatonin or any other known ligand. MT and MT are involved in various biological functions including the regulation of biological rhythms, sleep, pain, retinal, neuronal 1 2 and immune functions. Alteration of melatonin receptor function or expression in humans is associated with depression, Alzheimer’s disease and type 2 diabetes. www.MedChemE 1 Melatonin Receptor Agonists, Activators Antagonists 2-Iodomelatonin 4-P-PDOT Cat. No.: HY-101176 Cat. No.: HY-100609 2-Iodomelatonin is a potent agonist of 4-P-PDOT is a potent, selective and affinity melatonin receptor 1 (MT1) with a K value Melatonin receptor (MT2) antagonist. i of 28 pM, it is more 5-fold selective for MT1