PTEN-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

PTEN Phosphatase and tensin homolog; MMAC1 PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. www.MedChemE 1 PTEN Inhibitors Activators Afzelin BpV(HOpic) (Kaempferol-3-O-rhamnoside) Cat. No.: HY-N1441 Cat. No.: HY-128693 Afzelin (Kaempferol-3-O-rhamnoside) is is a BpV(HOpic) is a potent and selective inhibitor of flavonol glycoside found in Houttuynia cordata PTEN with an IC50 of 14 nM. Thunberg and is widely used in the preparation of Nanocarrier-BpV(HOpic) has neuroprotective antibacterial and antipyretic agents, detoxicants activity. and for the treatment of inflammation. Purity: 99.62% Purity: ≥95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Siz