MALT1-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors. www.MedChemE 1 MALT1 Inhibitors (R)-MALT1-IN-3 (R)-MALT1-IN-7 Cat. No.: HY-143422A Cat. No.: HY-143425A (R)-MALT1-IN-3 (compound 121) is a potent MALT1 (R)-MALT1-IN-7 (compound 142a) is a potent protease inhibitor with an IC50 of 20 nM. MALT1 protease inhibitor. (R)-MALT1-IN-7 hasn (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human bsp;the potential for cancer r IL6/IL10 in OCI-LY3 cells, respectively. esearch. Purity: 98% Purity: 98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg