MAP3K-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

MAP3K MAP kinase kinase kinase, MEKK, MAPKKK MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, provide specificity for stimulus-dependent activation of MAP2K-MAPK pathways through unique protein-protein interactions and phosphorylation of signaling effectors. The MAP3Ks are highly divergent in gene numbers and structure, including TAK1, ASK1, A-Raf and C-Raf. MAPK system is a three-step sequential phosphorylation cascade which is composed of MAPK, MAP2K, and MAP3K. ERK, p38 MAPK, and JNK, which are known to be activated by mechanical stimuli, belong to the MAPK family. MAP3Ks function as “platforms to integrate MAPK signaling, and activation of multiple MAP3Ks provides the spatiotemporal regulation of the MAPK pathways, which induces a wide range of physiological responses required for determining cell fate, such as cytokine production, survival, differentiation and apoptosis”. www.MedChemE 1 MAP3K Inhibitors 5Z-7-Oxozeaenol ASK1-IN-2 (FR148083; L783279; LL-Z 1640-2) Cat. No.: HY-12686 Cat. No.: HY-131969 5Z-7-Oxozeaenol is a natural anti-protozoan ASK1-IN-2 is a potent and orally active inhibitor compound from fungal origin, acting as a potent of apoptosis signal-regulating kinase 1 (ASK1), irreversible and selective inhibitor of TAK1 and with an IC of 32.8 nM. ASK1-IN-2 can be used for