PDK-1-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

PDK-1-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

  1. 1、本文档共3页,可阅读全部内容。
  2. 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
PDK-1 3-Phosphoinositide-dependent protein kinase 1 PDK-1 (3-Phosphoinositide-dependent protein kinase 1), a member of the protein A, G and C (AGC) family of proteins, is a Ser/Thr protein kinase. PDK-1, is the pivotal node in the PI3K pathway, has a key role in insulin and growth-factor signalling through phosphorylation and subsequent activation of a number of other AGC kinase family members, such as protein kinase B. PDK-1 is responsible for the regulation of cell proliferation and migration and it also has been found to play a key role in different cancers, pancreatic and breast cancer amongst others. Many cancer-driving mutations induce activation of PDK-1 targets including Akt, S6K (p70 ribosomal S6 kinase) and SGK. Thus, PDK1 is a critical activator of multiple pro-survival and oncogenic protein kinases, for which it has garnered considerable interest as an oncology drug target. www.MedChemE 1 PDK-1 Inhibitors Activators (R)-PS210 BX-320 Cat. No.: HY-13856 Cat. No.: HY-10515 (R)-PS210, the R enantiomer of PS210 (compound BX-320 is a selective, ATP-competitive, orally 4h-eutomer), is a substrate-selective allosteric acitive, and direct PDK1 inhibitor with an IC50 activator of PDK1 with an AC50 value of 1.8 μM. of 30 nM in a direct kinase assay format. BX-320 (R)-PS210 targets to the PIF-binding pocket also induces apoptosis. Anticancer effect.

文档评论(0)

Medchemexpress + 关注
官方认证
内容提供者

MCE (MedChemExpress) 是全球领先的科研化学品和生物活性化合物供应商。MCE 的产品范围覆盖各种抑制剂、激动剂和化合物库。

版权声明书
用户编号:6121102212000052
认证主体上海皓元生物医药科技有限公司
IP属地上海
统一社会信用代码/组织机构代码
9131000068553264X2

1亿VIP精品文档

相关文档