Pyk2-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Pyk2 Proline-rich tyrosine kinase 2 Proline-rich tyrosine kinase 2 (Pyk2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment. Pyk2 and focal adhesion kinase (FAK) comprise the focal adhesion kinase subfamily of non-receptor tyrosine kinases. PYK2 and FAK are large multidomain proteins containing an N-terminal FERM domain, a central catalytic domain, and a C-terminal segment containing dual proline rich (PR) subdomains and a focal adhesion targeting (FAT) region. Pyk2, a non-receptor tyrosine kinase of the FAK family, is up-regulated in more than 60% of the tumors of hepatocellular carcinoma (HCC) patients. www.MedChemE 1 Pyk2 Inhibitors NVP-TAE 226 PF-431396 (TAE226) Cat. No.: HY-13203 Cat. No.: HY-10460 NVP-TAE 226 (TAE226) is a potent and PF-431396 is an orally active dual focal adhesion ATP-competitive dual FAK and IGF-1R inhibitor with kinase (FAK) and proline-rich tyrosine kinase 2 IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE (PYK2) inhibitor, with IC50 values of 2 nM and 11 226 (TAE226) also effectively inhibits Pyk2 and nM, respectively. insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively. Purity: 99.92% Purity: 98.86% Cli