5-alpha-Reductase-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

5 alpha Reductase 5α-reductase Steroid 5-α reductase (5AR) is a membrane-bound protein that is responsible for reducing steroids such as testosterone, progesterone, and androstenedione to 5-α reduced metabolites such as 5-α dihydrotestosterone (DHT), 5-α dihydroprogesterone and androstanedione, respectively. There are three isoforms of 5AR in humans: SRD5A1, SRD5A2, and SRD5A3. SRD5A1 and SRD5A2 have functionality for 5-α reduction of steroids in humans. DHT is a more potent androgen than testosterone and has a function in androgen receptor activation. The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases. www.MedChemE 1 5 alpha Reductase Inhibitors 12-O-Methylcarnosic acid 5α-reductase-IN-1 (12-Methoxycarnosic acid) Cat. No.: HY-N7510 Cat. No.: HY-U00376 12-O-Methylcarnosic acid (12-Methoxycarnosic 5α-reductase-IN-1 is an inhibitor of acid), a diterpene carnosic acid isolated from the 5α-reductase, used for the research of patterned acetone extract of Salvia microphylla, is an alopecia in combination with minoxidil. active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. Purity: 99.72% Purity: 98% Clinical