PIKfyve-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

PIKfyve FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase; Fab1 PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene. The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns(3,5)P2. PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). PIKfyve is a large protein, containing a number of functional domains and expressed in several spliced forms. By directly binding membrane PtdIns(3)P, the FYVE finger domain of PIKfyve is essential in localizing the protein to the cytosolic leaflet of endosomes. Impaired PIKfyve enzymatic activity by dominant-interfering mutants, siRNA- mediated ablation or pharmacological inhibition causes endosome enlargement and cytoplasmic vacuolation due to impaired PtdIns(3,5)P2 synthesis. Thus, via PtdIns(3,5)P2 production, PIKfyve participates in several aspects of endosome dynamics, thereby affecting a number of trafficking pathways that emanate from or traverse the endosomal system en route to the trans-Golgi network or later compartments along the endocytic pathway. www.MedChemE 1 PIKfyve Inhibitors Apilimod Apilimod mesylate (STA 5326) Cat. No.: HY-14644 (STA 5326 mesylate) Cat. No.: HY-14644A Apilimod (STA 5326) is a potent IL-12/IL-23 Apilimod (STA 5326) mesylate is a potent inhibitor, and strongly inhibits IL-12 with IC50s IL-12/IL-23 inhibitor, and stron