Raf-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

Raf Raf kinases Raf kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. Raf kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members are: A-Raf, B-Raf, C-Raf (Raf-1). The B-Raf protein is involved in sending signals inside cells, which are involved in directing cell growth. It was shown to be faulty (mutated) in some human cancers. C-RAF or even Raf-1 is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase kinase kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases. www.MedChemE 1 Raf Inhibitors (Z)-GW 5074 AD80 Cat. No.: HY-10542A Cat. No.: HY-101963 (Z)-GW 5074 is a compound which interacts with AD80, a multikinase inhibitor, inhibits RET, both mHTT (mutant huntingtin protein) and LC3, RAF,SRCand S6K, with greatly reduced mTOR but not but not with the wild-type HTT protein. activity. (Z)-GW 5074 inhibits c-Raf, shows no effect on autophagy, and is effective for ne