SGLT-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

SGLT Sodium-dependent glucose cotransporters SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption. The two most well-known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. The two transporters are of primary importance for glucose homeostasis by absorbing glucose from the diet in the small intestine (via SGLT1) and by reabsorbing the filtered glucose in the tubular system of the kidney (primarily SGLT2; to smaller extent via SGLT1); the latter process returns glucose into the blood stream and prevents urinary glucose loss. SGLT1 and SGLT2 have been proposed as a novel therapeutic strategy for diabetes and cardiomyopathy. www.MedChemE 1 SGLT Inhibitors Canagliflozin Canagliflozin hemihydrate (JNJ Cat. No.: HY-10451 (JNJhemihydrate) Cat. No.: HY-I0383 Canagliflozin (JNJ is a selective SGLT2 Canagliflozin hemihydrate (JN inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM hemihydrate) is a selective SGLT2 inhibitor with for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, respectively. rSGLT2, and hSGLT2 in CHOK cells, respectively. Purity: 99.66% Purity: 99.95% Clinical Data: Launc