BPN-15606-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE BPN-15606 Cat. No.: HY-117482 CAS No.: 1914989-49-3 分⼦式: C₂₃H₂₃FN₆O 分⼦量: 418.47 作⽤靶点: γ-secretase 作⽤通路: Neuronal Signaling; Stem Cell/Wnt 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 BPN-15606 是⼀种⾼效的⼝服活性 γ-secretase 调节剂 (GSM)，可减弱 SHSY5Y 神经母细胞瘤细胞产⽣ A β42 和 A β40 的作⽤，IC50 值分别为 7 nM 和 17 nM。BPN-15606 显着降低⼤⿏和⼩⿏中枢神经系统中的 A β42 和 A β40 ⽔平。BPN-15606 具有良好的 PK/PD 特性，包括⽣物利⽤度，半衰期和清除率。 IC50 Target γ-secretase [1] 体内研究 BPN-15606 (oral administration; 10 mg/kg, 25 mg/kg and 50 mg/kg; 7 days) shows excellent dose-dependent efficacy in both plasma and brain on lowering of Aβ42 and Aβ40 levels in mice [1].BPN-15606 (oral administration; 5 mg/kg, 25 mg/kg and 50 mg/kg; 9 days) dose-dependently reduces CSF on lowering of A β42 and Aβ40 levels in rats [1].BPN-15606 (oral administration; 25 mg/kg; single dose) shows a robust effect on both brain and plasma Aβ 42 and Aβ40 levels, which begins approximately 30–60 minutes following