Chelerythrine-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Chelerythrine Cat. No.: HY-N2359 CAS No.: 34316-15-9 分⼦式: C₂₁H₁₈NO₄ 分⼦量: 348.37 作⽤靶点: PKC 作⽤通路: Epigenetics; TGF-beta/Smad 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Chelerythrine 是⼀种天然⽣物碱，为有效、选择性的 Ca2+/磷脂依赖性 PKC 拮抗剂，IC50 值为 0.7 μM [1]。 Chelerythrine 具有抗肿瘤、抗糖尿病、抗炎的活性 [2]。 IC50 Target PKC 0.7 μM (IC50) REFERENCES [1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9. [2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021 Fax: 021 E-mail: tech@MedChemE 1/1