Bozitinib-PLB-1001-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Bozitinib Cat. No.: HY-125017 CAS No.: 1440964-89-5 Synonyms: PLB-1001; CBT-101 分⼦式: C₂₀H₁₅F₃N₈ 分⼦量: 424.38 作⽤靶点: c-Met/HGFR 作⽤通路: Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Bozitinib (PLB-1001) 是⼀种可通过⾎脑屏障的⾼选择性 c-MET 激酶抑制剂。Bozitinib (PLB-1001) 是 ATP 竞争 性⼩分⼦抑制剂，与酪氨酸激酶超家族的常规 ATP 结合⼝袋结合。 体外研究 Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways. Western Blot Analysis [1] Cell Line: Human astrocytes (HA) cells Concentration: 30 μM Incubation Time: 6 hours Result: Decreased p-STAT3,p-MET expression. REFERENCES [1]. Hu H, et al. Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell. 2018 Nov 29;175(6):1665-1678.e18. McePdfHeight 1/1