Deoxyshikonin-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Deoxyshikonin Cat. No.: HY-N2187 CAS No.: 43043-74-9 分⼦式: C₁₆H₁₆O₄ 分⼦量: 272.3 作⽤靶点: Bacterial; HIF/HIF Prolyl-Hydroxylase 作⽤通路: Anti-infection; Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Deoxyshikonin 从紫草 Lithospermum erythrorhizon 中分离，具有抗肿瘤活性。Deoxyshikonin增加 HMVEC- dLy 中 VEGF-C 和 VEGF-A mRNA 的表达，促进 HIF-1 α 和 HIF-1 β 亚基相互作⽤，并与 HIF 特异性 DNA 序列 结合。Deoxyshikonin 在体外具有促⾎管⽣成作⽤。Deoxyshikonin 显⽰出显着的协同抗微⽣物活性, S. pneumonia (MIC =17 μg/mL)，也显⽰出对 MRSA 的显着抑制活性。 REFERENCES [1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297. [2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479. McePdfHeight Caution: Product has not been fully validated for medical applications.