计算系统生物学简介.ppt

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* 计算系统生物学简介 崔庆华 2008-3-14 第一页,共三十三页。 Outline 计算系统生物学简介 网络的数学模型 网络可视化工具Pajek 无尺度网络和小世界网络 第二页,共三十三页。 生物信息学的分支 Bioinformatics is defined as a scientific discipline that encompasses all aspects of biological information acquisition, processing, storage, distribution, analysis and interpretation, that combines the tools and techniques of mathematics, computer science and biology with the aim of understanding the biological significance of a variety of data. 第三页,共三十三页。 第四页,共三十三页。 生物信息学的兴起 Data…… ★ Large-scale and high-throughput ★ High-dimensional ★ Non-linear ★ Noisy ★ Unequally distributed 第五页,共三十三页。 What is Systems Biology? Not a new concept! Systems biology is an emergent field that aims at system-level understanding of biological systems (Kitano 2002). To understand biology at the system level, we must examine the structure and dynamics and cellular organismal function, rather than the characteristics of isolated parts of a cell or organism. 第六页,共三十三页。 Systems的层次性 第七页,共三十三页。 Why Systems Biology? + + + _ 0 A B C D E 第八页,共三十三页。 Why Computational Systems Biology? Golden opportunity, now! ★ More than 16 international meetings in 2006 ★ More than 10 books in the past two years ★ Journals: Molecular systems biology (Nature EMBO), BMC systems biology, IET systems biology, EURASIP Journal on Bioinformatics and Systems Biology etc. Large-scale, high-throughput data 第九页,共三十三页。 Fields of Computational Systems Biology? Biological networks construction, such as gene regulatory networks, cellular signaling networks, metabolic networks, protein-protein interaction networks, genetic interaction networks, gene co-expression networks, literature networks. 第十页,共三十三页。 Fields of Computational Systems Biology? Properties of systems, such as topology, robustness, tolerance. Albert et al., Nature 2000 第十一页,共三十三页。 Fields of Computational Systems Biology? Goh et al., PNAS 2007 P53 region TGFβ region Ras region Cui et al., MSB 2007 Biological questions on systems-levels, such as diseases,

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