AZD-7648-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AZD-7648 Cat. No.: HY-111783 CAS No.: 2230820-11-6 分⼦式: C₁₈H₂₀N₈O₂ 分⼦量: 380.4 作⽤靶点: DNA-PK 作⽤通路: Cell Cycle/DNA Damage; PI3K/Akt/mTOR 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 溶解性数据 体外实验 DMSO : 5 mg/mL (13.14 mM; ultrasonic and warming and heat to 80°C) Mass Solvent 1 mg 5 mg 10 mg Concentration 制备储备液 1 mM 2.6288 mL 13.1441 mL 26.2881 mL 5 mM 0.5258 mL 2.6288 mL 5.2576 mL 10 mM 0.2629 mL 1.3144 mL 2.6288 mL 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。 BIOLOGICAL ACTIVITY ⽣物活性 AZD-7648 是⼀种有效的选择性 DNA-PK 抑制剂，具有抗肿瘤活性 [1]。 IC50 Target DNA-PK [1] REFERENCES [1]. Maurice Raymond Verschoyle Finlay, et al. Amino-triazolopyridine compounds and their use in treating cancer. WO2018114999A1. 1/2