Cyasterone-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Cyasterone Cat. No.: HY-N0211 CAS No.: 17086-76-9 分⼦式: C₂₉H₄₄O₈ 分⼦量: 520.65 作⽤靶点: EGFR 作⽤通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Cyasterone，⼀种天然的 EGFR 抑制剂，主要分离⾃ Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过 诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作⽤。 Cyasterone 可作为抗⼈类肿瘤的临床治疗性药 物。 体外研究 Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively [1]. Cell Viability Assay [1] Cell Line: A549, HCT116, MGC823 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells. REFERENCES [1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother.