Dynorphin-A-1-10-TFA-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Dynorphin A (1-10) TFA Cat. No.: HY-P1594A 分⼦式: C₅₉H₉₂F₃N₁₉O₁₄ 分⼦量: 1348.48 Sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro Sequence Shortening: YGGFLRRIRP 作⽤靶点: Opioid Receptor; iGluR 作⽤通路: GPCR/G Protein; Neuronal Signaling; Membrane Transporter/Ion Channel 储存⽅式: Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Dynorphin A (1-10) (TFA) 是⼀种内源性的阿⽚样神经肽，与 κ 阿⽚受体 ( κ-opioid receptor) 结合。 Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。 IC50 Target κ-opioid receptor [1] IC50: 42.0 μM (NMDA receptor) [2] 体外研究 Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds in the transmembrane domain of the κ- receptor [1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D- aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage- independent. The IC50 is 42.0 μM for DynA(1-10). To determine if shorter dyn