L-779450-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE L-779450 Cat. No.: HY-12787 CAS No.: 303727-31-3 分⼦式: C₂₀H₁₄ClN₃O 分⼦量: 347.8 作⽤靶点: Raf; Autophagy 作⽤通路: MAPK/ERK Pathway; Autophagy 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month 溶解性数据 体外实验 DMSO : ≥ 34 mg/mL (97.76 mM) * ≥ means soluble, but saturation unknown. Mass Solvent 1 mg 5 mg 10 mg Concentration 制备储备液 1 mM 2.8752 mL 14.3761 mL 28.7522 mL 5 mM 0.5750 mL 2.8752 mL 5.7504 mL 10 mM 0.2875 mL 1.4376 mL 2.8752 mL 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。 BIOLOGICAL ACTIVITY ⽣物活性 L-779450 是⼀种有效的选择性 B-Raf 抑制剂，Kd 为 2.4 nM。 IC50 Target B-Raf 2.4 nM (Kd) 体外研究 L-779450 (L-779,450) shows a high degree of specificity towards Raf. The only other tested kinase inhibited 1/2